The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders – relation to drug treatment Norbert Müller, MD, PhD, DipPsych Dialogues Clin Neurosci. 2009;11(3):319-332.7 An inflammatory pathogenesis has been postulated for schizophrenia and major depression (MD). In schizophrenia and depression, opposing patterns oftype-1 vs type-2 immune response seem to be associated with differences in the activation of the enzyme indoleamine 2,3-dioxygenase and in the tryptophan-kynurenine metabolism, resulting in increased production of kynurenic acid in schizophrenia and decreased production of kynurenic acid in depression. These differences are associated with…